Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes

Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding their mechanism of activation. Here, by successfully mapping topoisomerase I–DNA covalent complexes genome-wide, we find that m...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Yuliang, Yao, Lu, Gamliel, Amir, Nair, Sreejith J., Taylor, Havilah, Ohgi, Kenny, Aggarwal, Aneel K., Rosenfeld, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935399/
https://www.ncbi.nlm.nih.gov/pubmed/36747093
http://dx.doi.org/10.1038/s41594-022-00883-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935399/
https://www.ncbi.nlm.nih.gov/pubmed/36747093
http://dx.doi.org/10.1038/s41594-022-00883-8

Ejemplares similares