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Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes

Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding their mechanism of activation. Here, by successfully mapping topoisomerase I–DNA covalent complexes genome-wide, we find that m...

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Detalles Bibliográficos
Autores principales:	Tan, Yuliang, Yao, Lu, Gamliel, Amir, Nair, Sreejith J., Taylor, Havilah, Ohgi, Kenny, Aggarwal, Aneel K., Rosenfeld, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935399/ https://www.ncbi.nlm.nih.gov/pubmed/36747093 http://dx.doi.org/10.1038/s41594-022-00883-8

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