Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle

We investigate the age-related metabolic changes that occur in aged and rejuvenated myoblasts using in vitro and in vivo models of aging. Metabolic and signaling experiments reveal that human senescent myoblasts and myoblasts from a mouse model of premature aging suffer from impaired glycolysis, ins...

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Detalles Bibliográficos
Autores principales: Rajabian, Nika, Ikhapoh, Izuagie, Shahini, Shahryar, Choudhury, Debanik, Thiyagarajan, Ramkumar, Shahini, Aref, Kulczyk, Joseph, Breed, Kendall, Saha, Shilpashree, Mohamed, Mohamed Alaa, Udin, Susan B., Stablewski, Aimee, Seldeen, Kenneth, Troen, Bruce R., Personius, Kirkwood, Andreadis, Stelios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935517/
https://www.ncbi.nlm.nih.gov/pubmed/36797255
http://dx.doi.org/10.1038/s41467-023-36483-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935517/
https://www.ncbi.nlm.nih.gov/pubmed/36797255
http://dx.doi.org/10.1038/s41467-023-36483-3

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