Cargando…

Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle

We investigate the age-related metabolic changes that occur in aged and rejuvenated myoblasts using in vitro and in vivo models of aging. Metabolic and signaling experiments reveal that human senescent myoblasts and myoblasts from a mouse model of premature aging suffer from impaired glycolysis, ins...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajabian, Nika, Ikhapoh, Izuagie, Shahini, Shahryar, Choudhury, Debanik, Thiyagarajan, Ramkumar, Shahini, Aref, Kulczyk, Joseph, Breed, Kendall, Saha, Shilpashree, Mohamed, Mohamed Alaa, Udin, Susan B., Stablewski, Aimee, Seldeen, Kenneth, Troen, Bruce R., Personius, Kirkwood, Andreadis, Stelios T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935517/ https://www.ncbi.nlm.nih.gov/pubmed/36797255 http://dx.doi.org/10.1038/s41467-023-36483-3

Ejemplares similares

Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo
por: Shahini, Aref, et al.
Publicado: (2021)

Reversine ameliorates hallmarks of cellular senescence in human skeletal myoblasts via reactivation of autophagy
por: Rajabian, Nika, et al.
Publicado: (2023)

Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells
por: Choudhury, Debanik, et al.
Publicado: (2022)

Efficient and high yield isolation of myoblasts from skeletal muscle
por: Shahini, Aref, et al.
Publicado: (2018)

Fast photocurable thiol-ene elastomers with tunable biodegradability, mechanical and surface properties enhance myoblast differentiation and contractile function
por: Mohamed, Mohamed Alaa, et al.
Publicado: (2021)

Cognitively Impaired Old Mice Display Correlated Reduction in Cortical NMDA Receptor and Complex IV
por: Thiyagarajan, Ramkumar, et al.
Publicado: (2020)

Capture of endothelial cells under flow using immobilized vascular endothelial growth factor
por: Smith, Randall J., et al.
Publicado: (2015)

Methionine adenosyltransferases in liver cancer
por: Murray, Ben, et al.
Publicado: (2019)

Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis
por: Ramani, Komal, et al.
Publicado: (2011)

Implications of divergence of methionine adenosyltransferase in archaea
por: Chouhan, Bhanu Pratap Singh, et al.
Publicado: (2021)

Both Vitamin D Supplementation and HIIT Boost Muscle VDR Expression, Which May Underlie Benefits for Frailty
por: Seldeen, Ken, et al.
Publicado: (2021)

Impact of glutathione supplementation of parenteral nutrition on hepatic methionine adenosyltransferase activity
por: Elremaly, Wesam, et al.
Publicado: (2015)

SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of Sirt1
por: Thiyagarajan, Ramkumar, et al.
Publicado: (2023)

Blockage of neuromuscular glutamate receptors impairs reinnervation following nerve crush in adult mice
por: Personius, Kirkwood E., et al.
Publicado: (2022)

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases
por: Pérez, Claudia, et al.
Publicado: (2016)

PEGylated Amine-Functionalized Poly(ε-caprolactone) for the Delivery of Plasmid DNA
por: Jafari, Amin, et al.
Publicado: (2020)

Comparison of Glycemic Excursion in Patients with New Onset Type 2 Diabetes Mellitus before and after Treatment with Repaglinide
por: Hezarkhani, Sharabeh, et al.
Publicado: (2013)

Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis
por: Berger, Bradley J, et al.
Publicado: (2003)

Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis
por: Schlesier, Julia, et al.
Publicado: (2013)

Correction: The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases
por: Pérez, Claudia, et al.
Publicado: (2016)

Methionine Adenosyltransferase I/III Deficiency Detected by Newborn Screening
por: Hübner, Vanessa, et al.
Publicado: (2022)

Synergistic effect of angiotensin II on vascular endothelial growth factor-A-mediated differentiation of bone marrow-derived mesenchymal stem cells into endothelial cells
por: Ikhapoh, Izuagie Attairu, et al.
Publicado: (2015)

Atherogenic Cytokines Regulate VEGF-A-Induced Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells
por: Ikhapoh, Izuagie Attairu, et al.
Publicado: (2015)

Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases
por: Gade, Madhuri, et al.
Publicado: (2021)

Evolution of homo‐oligomerization of methionine S‐adenosyltransferases is replete with structure–function constrains
por: Kleiner, Daniel, et al.
Publicado: (2022)

Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
por: Seldeen, Kenneth Ladd, et al.
Publicado: (2020)

Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells
por: Phuong, Nguyen Thi Thuy, et al.
Publicado: (2015)

Methionine adenosyltransferase I/III deficiency: beyond the central nervous system manifestations
por: Nashabat, Marwan, et al.
Publicado: (2018)

SAMase of Bacteriophage T3 Inactivates Escherichia coli’s Methionine S-Adenosyltransferase by Forming Heteropolymers
por: Simon-Baram, Hadas, et al.
Publicado: (2021)

Correction to “Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases”
por: Gade, Madhuri, et al.
Publicado: (2022)

Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?
por: Seldeen, Kenneth Ladd, et al.
Publicado: (2021)

Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells
por: Kwack, Kyu Hwan, et al.
Publicado: (2022)

2′,6′-Dihalostyrylanilines, Pyridines, and Pyrimidines for the Inhibition of the Catalytic Subunit of Methionine S-Adenosyltransferase-2
por: Sviripa, Vitaliy M., et al.
Publicado: (2014)

Polar Interactions at the Dimer–Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization
por: Sánchez-Pérez, Gabino Francisco, et al.
Publicado: (2021)

Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits
por: Shafqat, Naeem, et al.
Publicado: (2013)

Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis
por: Wang, Xuliang, et al.
Publicado: (2014)

Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions
por: Ikeda, Shuntaro, et al.
Publicado: (2017)

Long-term prognosis of 35 patients with methionine adenosyltransferase deficiency based on newborn screening in China
por: Tong, Fan, et al.
Publicado: (2023)

NADP(+) Binding to the Regulatory Subunit of Methionine Adenosyltransferase II Increases Intersubunit Binding Affinity in the Hetero-Trimer
por: González, Beatriz, et al.
Publicado: (2012)

Biosynthesis of S-Adenosylmethionine by Magnetically Immobilized Escherichia coli Cells Highly Expressing a Methionine Adenosyltransferase Variant
por: Yin, Chunli, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pq3508r2qic6j9oe0h2rfr9g47