Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly

Three RNA helicases – DDX42, DDX46 and DHX15 – are found to be associated with human U2 snRNP, but their roles and mechanisms in U2 snRNP and spliceosome assembly are insufficiently understood. Here we report the cryo-electron microscopy (cryo-EM) structures of the DDX42-SF3b complex and a putative...

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Detalles Bibliográficos
Autores principales: Yang, Fenghua, Bian, Tong, Zhan, Xiechao, Chen, Zhe, Xing, Zhihan, Larsen, Nicolas A., Zhang, Xiaofeng, Shi, Yigong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935549/
https://www.ncbi.nlm.nih.gov/pubmed/36797247
http://dx.doi.org/10.1038/s41467-023-36489-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935549/
https://www.ncbi.nlm.nih.gov/pubmed/36797247
http://dx.doi.org/10.1038/s41467-023-36489-x

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