Structural basis for membrane attack complex inhibition by CD59

CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane attack complex (MAC) pores. We present cryo-electro...

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Detalles Bibliográficos
Autores principales: Couves, Emma C., Gardner, Scott, Voisin, Tomas B., Bickel, Jasmine K., Stansfeld, Phillip J., Tate, Edward W., Bubeck, Doryen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935631/
https://www.ncbi.nlm.nih.gov/pubmed/36797260
http://dx.doi.org/10.1038/s41467-023-36441-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935631/
https://www.ncbi.nlm.nih.gov/pubmed/36797260
http://dx.doi.org/10.1038/s41467-023-36441-z

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