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AAV- based vector improvements unrelated to capsid protein modification

Recombinant adeno-associated virus (rAAV) is the leading platform for delivering genetic constructs in vivo. To date, three AAV-based gene therapeutic agents have been approved by the FDA and are used in clinical practice. Despite the distinct advantages of gene therapy development, it is clear that...

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Detalles Bibliográficos
Autores principales: Shitik, Ekaterina M., Shalik, Igor K., Yudkin, Dmitry V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935841/
https://www.ncbi.nlm.nih.gov/pubmed/36817775
http://dx.doi.org/10.3389/fmed.2023.1106085