Network of hotspot interactions cluster tau amyloid folds

Cryogenic electron microscopy has revealed unprecedented molecular insight into the conformations of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It remains unknown how a protein can adopt a diversity of folds and form multiple distinct fibrillar structures. Here we develop an...

Descripción completa

Detalles Bibliográficos
Autores principales: Mullapudi, Vishruth, Vaquer-Alicea, Jaime, Bommareddy, Vaibhav, Vega, Anthony R., Ryder, Bryan D., White, Charles L., Diamond, Marc. I., Joachimiak, Lukasz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935906/
https://www.ncbi.nlm.nih.gov/pubmed/36797278
http://dx.doi.org/10.1038/s41467-023-36572-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935906/
https://www.ncbi.nlm.nih.gov/pubmed/36797278
http://dx.doi.org/10.1038/s41467-023-36572-3

Ejemplares similares