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Network of hotspot interactions cluster tau amyloid folds

Cryogenic electron microscopy has revealed unprecedented molecular insight into the conformations of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It remains unknown how a protein can adopt a diversity of folds and form multiple distinct fibrillar structures. Here we develop an...

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Detalles Bibliográficos
Autores principales:	Mullapudi, Vishruth, Vaquer-Alicea, Jaime, Bommareddy, Vaibhav, Vega, Anthony R., Ryder, Bryan D., White, Charles L., Diamond, Marc. I., Joachimiak, Lukasz A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935906/ https://www.ncbi.nlm.nih.gov/pubmed/36797278 http://dx.doi.org/10.1038/s41467-023-36572-3

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