Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype

Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and chromosomal instability. Moreover, Plk4 deregulation promo...

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Detalles Bibliográficos
Autores principales: Fonseca, Irina, Horta, Cíntia, Ribeiro, Ana Sofia, Sousa, Barbara, Marteil, Gaëlle, Bettencourt-Dias, Mónica, Paredes, Joana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935921/
https://www.ncbi.nlm.nih.gov/pubmed/36797240
http://dx.doi.org/10.1038/s41419-023-05618-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935921/
https://www.ncbi.nlm.nih.gov/pubmed/36797240
http://dx.doi.org/10.1038/s41419-023-05618-1

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