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The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis

OBJECTIVES: The mammalian target of Rapamycin (mTOR) is a metabolic master regulator of both innate and adaptive immunity; however, its exact role in stromal cell biology is unknown. In this study we explored the role of the mTOR pathway on Rheumatoid Arthritis synovial fibroblast (RASF) metabolism...

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Detalles Bibliográficos
Autores principales: Barker, Brianne E., Hanlon, Megan M., Marzaioli, Viviana, Smith, Conor M., Cunningham, Clare C., Fletcher, Jean M., Veale, Douglas J., Fearon, Ursula, Canavan, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936094/
https://www.ncbi.nlm.nih.gov/pubmed/36817783
http://dx.doi.org/10.3389/fmed.2023.1029021