Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography

The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology introduces chemical triggers that allow the changing of ligand affinities and thus biological activity by light. Insight into the molecular mec...

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Detalles Bibliográficos
Autores principales: Wranik, Maximilian, Weinert, Tobias, Slavov, Chavdar, Masini, Tiziana, Furrer, Antonia, Gaillard, Natacha, Gioia, Dario, Ferrarotti, Marco, James, Daniel, Glover, Hannah, Carrillo, Melissa, Kekilli, Demet, Stipp, Robin, Skopintsev, Petr, Brünle, Steffen, Mühlethaler, Tobias, Beale, John, Gashi, Dardan, Nass, Karol, Ozerov, Dmitry, Johnson, Philip J. M., Cirelli, Claudio, Bacellar, Camila, Braun, Markus, Wang, Meitian, Dworkowski, Florian, Milne, Chris, Cavalli, Andrea, Wachtveitl, Josef, Steinmetz, Michel O., Standfuss, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936131/
https://www.ncbi.nlm.nih.gov/pubmed/36807348
http://dx.doi.org/10.1038/s41467-023-36481-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936131/
https://www.ncbi.nlm.nih.gov/pubmed/36807348
http://dx.doi.org/10.1038/s41467-023-36481-5

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