Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese

In earlier physiologically based pharmacokinetic (PBPK) models for manganese (Mn), the kinetics of transport of Mn into and out of tissues were primarily driven by slow rates of association and dissociation of Mn with tissue binding sites. However, Mn is known to show rapidly reversible binding in t...

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Detalles Bibliográficos
Autores principales: Campbell, Jerry L, Clewell, Harvey J, Van Landingham, Cynthia, Gentry, P Robinan, Keene, Athena M, Taylor, Michael D, Andersen, Melvin E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Computational Toxicology and Databases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936208/
https://www.ncbi.nlm.nih.gov/pubmed/36453847
http://dx.doi.org/10.1093/toxsci/kfac123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936208/
https://www.ncbi.nlm.nih.gov/pubmed/36453847
http://dx.doi.org/10.1093/toxsci/kfac123

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