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EGFR promotes the apoptosis of CD4(+) T lymphocytes through TBK1/Glut1 induced Warburg effect in sepsis
INTRODUCTION: Sepsis-induced apoptosis leads to lymphopenia including the decrease of CD4(+) T cells thus favoring immunosuppression. OBJECTIVES: Although epidermal growth factor receptor (EGFR) inhibitors significantly improve the survival rate of septic mice, the effect of EGFR on the function and...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936423/ https://www.ncbi.nlm.nih.gov/pubmed/35618635 http://dx.doi.org/10.1016/j.jare.2022.04.010 |