EGFR promotes the apoptosis of CD4(+) T lymphocytes through TBK1/Glut1 induced Warburg effect in sepsis

INTRODUCTION: Sepsis-induced apoptosis leads to lymphopenia including the decrease of CD4(+) T cells thus favoring immunosuppression. OBJECTIVES: Although epidermal growth factor receptor (EGFR) inhibitors significantly improve the survival rate of septic mice, the effect of EGFR on the function and...

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Detalles Bibliográficos
Autores principales: Huang, Li, Zhang, Xuedi, Fan, Junyu, Liu, Xiaolei, Luo, Shuhua, Cao, Dianqing, Liu, Youtan, Xia, Zhengyuan, Zhong, Hanhui, Chen, Cuiping, Zhang, Liangqing, Liu, Zhifeng, Tang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936423/
https://www.ncbi.nlm.nih.gov/pubmed/35618635
http://dx.doi.org/10.1016/j.jare.2022.04.010

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