Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae

Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii, and its C-14 hydroxyl group is often selected for modification to enhance both the bioavailability and antitumor efficacy. However, the mechanism for 14-hydroxylation formation remains unknown. Here, we discover 13...

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Detalles Bibliográficos
Autores principales: Zhang, Yifeng, Gao, Jie, Ma, Lin, Tu, Lichan, Hu, Tianyuan, Wu, Xiaoyi, Su, Ping, Zhao, Yujun, Liu, Yuan, Li, Dan, Zhou, Jiawei, Yin, Yan, Tong, Yuru, Zhao, Huan, Lu, Yun, Wang, Jiadian, Gao, Wei, Huang, Luqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936527/
https://www.ncbi.nlm.nih.gov/pubmed/36797237
http://dx.doi.org/10.1038/s41467-023-36353-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936527/
https://www.ncbi.nlm.nih.gov/pubmed/36797237
http://dx.doi.org/10.1038/s41467-023-36353-y

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