Autophagy impairment in patients with obstructive sleep apnea modulates intermittent hypoxia-induced oxidative stress and cell apoptosis via hypermethylation of the ATG5 gene promoter region

BACKGROUND: Autophagy is a catabolic process that recycles damaged organelles and acts as a pro-survival mechanism, but little is known about autophagy dysfunction and epigenetic regulation in patients with obstructive sleep apnea (OSA). METHODS: Protein/gene expressions and DNA methylation levels o...

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Detalles Bibliográficos
Autores principales: Chen, Yung-Che, Lin, I-Chun, Su, Mao-Chang, Hsu, Po-Yuan, Hsiao, Chang-Chun, Hsu, Te-Yao, Liou, Chia-Wei, Chen, Yu-Mu, Chin, Chien-Hung, Wang, Ting-Ya, Chang, Jen-Chieh, Lin, Yong-Yong, Lee, Chiu-Ping, Lin, Meng-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936724/
https://www.ncbi.nlm.nih.gov/pubmed/36805797
http://dx.doi.org/10.1186/s40001-023-01051-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936724/
https://www.ncbi.nlm.nih.gov/pubmed/36805797
http://dx.doi.org/10.1186/s40001-023-01051-4

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