Inhibition of SMAD3 effectively reduces ADAMTS-5 expression in the early stages of osteoarthritis

OBJECTIVE: As one of the most important protein-degrading enzymes, ADAMTS-5 plays an important role in the regulation of cartilage homeostasis, while miRNA-140 is specifically expressed in cartilage, which can inhibit the expression of ADAMTS-5 and delay the progression of OA (osteoarthritis). SMAD3...

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Detalles Bibliográficos
Autores principales: Xiang, Wei, Wang, Chao, Zhu, Zhoujun, Wang, Dui, Qiu, Zhenyu, Wang, Weishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936734/
https://www.ncbi.nlm.nih.gov/pubmed/36803799
http://dx.doi.org/10.1186/s12891-022-05949-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936734/
https://www.ncbi.nlm.nih.gov/pubmed/36803799
http://dx.doi.org/10.1186/s12891-022-05949-8

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