A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection

Islatravir (MK-8591) is a deoxyadenosine analog in development for the treatment and prevention of HIV-1 infection. An islatravir-eluting implant could provide an additional option for pre-exposure prophylaxis (PrEP). SETTING: Previous data support a threshold islatravir triphosphate concentration f...

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Detalles Bibliográficos
Autores principales: Matthews, Randolph P., Zang, Xiaowei, Barrett, Stephanie E., Koynov, Athanas, Goodey, Adrian, Heimbach, Tycho, Weissler, Vanessa L., Leyssens, Carlien, Reynders, Tom, Xu, Zhiqing, Rottey, Sylvie, Vargo, Ryan, Robertson, Michael N., Stoch, S. Aubrey, Iwamoto, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2023
Materias:
Prevention Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936965/
https://www.ncbi.nlm.nih.gov/pubmed/36450129
http://dx.doi.org/10.1097/QAI.0000000000003135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936965/
https://www.ncbi.nlm.nih.gov/pubmed/36450129
http://dx.doi.org/10.1097/QAI.0000000000003135

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