TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life

TrYbe® is an Fc-free therapeutic antibody format, capable of engaging up to three targets simultaneously, with long in vivo half-life conferred by albumin binding. This format is shown by small-angle X-ray scattering to be conformationally flexible with favorable ‘reach’ properties. We demonstrate t...

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Detalles Bibliográficos
Autores principales: Davé, Emma, Durrant, Oliver, Dhami, Neha, Compson, Joanne, Broadbridge, Janice, Archer, Sophie, Maroof, Asher, Whale, Kevin, Menochet, Karelle, Bonnaillie, Pierre, Barry, Emily, Wild, Gavin, Peerboom, Claude, Bhatta, Pallavi, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P., Heywood, Sam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937000/
https://www.ncbi.nlm.nih.gov/pubmed/36788124
http://dx.doi.org/10.1080/19420862.2022.2160229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937000/
https://www.ncbi.nlm.nih.gov/pubmed/36788124
http://dx.doi.org/10.1080/19420862.2022.2160229

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