Cargando…

δ-Opioid Receptor Activation Inhibits Ferroptosis by Activating the Nrf2 Pathway in MPTP-Induced Parkinson Disease Models

INTRODUCTION: Recent studies suggest the involvement of ferroptosis in the pathogenesis of Parkinson disease (PD). δ-Opioid receptors (DORs) have neuroprotective effects in PD. It is not known whether the neuroprotective effects of DORs in PD are attributable to the inhibition of ferroptosis. Theref...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Benchi, Zhong, Lifan, Liu, Yanhui, Xu, Qian, Chen, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937764/ https://www.ncbi.nlm.nih.gov/pubmed/36818224 http://dx.doi.org/10.1155/2023/4130937

Ejemplares similares

Exploring the Neuroprotective Mechanism of Curcumin Inhibition of Intestinal Inflammation against Parkinson’s Disease Based on the Gut-Brain Axis
por: Zhong, Lifan, et al.
Publicado: (2022)

Quercetin Protects against MPP(+)/MPTP-Induced Dopaminergic Neuron Death in Parkinson's Disease by Inhibiting Ferroptosis
por: Lin, Zhi-Hao, et al.
Publicado: (2022)

Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor
por: Pu, Lu, et al.
Publicado: (2012)

Curcumin alleviates 1-methyl- 4-phenyl- 1,2,3,6-tetrahydropyridine- induced Parkinson’s disease in mice via modulating gut microbiota and short-chain fatty acids
por: Cai, Benchi, et al.
Publicado: (2023)

Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP(+)-induced models of Parkinson’s disease
por: Liu, Tongyu, et al.
Publicado: (2023)

Hair Growth Promotion by δ-Opioid Receptor Activation
por: Zheng, Mei, et al.
Publicado: (2021)

EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2
por: Wang, Bei, et al.
Publicado: (2023)

Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors
por: Gharagozlou, Parham, et al.
Publicado: (2002)

Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model
por: Liu, Yingjuan, et al.
Publicado: (2020)

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway
por: Guo, Zhou, et al.
Publicado: (2022)

Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease
por: Chung, Young C, et al.
Publicado: (2017)

The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson’s disease
por: Mounsey, R.B., et al.
Publicado: (2015)

δ-opioid Receptor, Microglia and Neuroinflammation
por: Xu, Yuan, et al.
Publicado: (2023)

PDSS2 Inhibits the Ferroptosis of Vascular Endothelial Cells in Atherosclerosis by Activating Nrf2
por: Yang, Kai, et al.
Publicado: (2021)

Corrigendum: Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway
por: Guo, Zhou, et al.
Publicado: (2023)

δ-Opioid receptor activation attenuates oxidative injury in the ischemic rat brain
por: Yang, Yilin, et al.
Publicado: (2009)

δ-Opioid Receptor Activation and MicroRNA Expression of the Rat Cortex in Hypoxia
por: Yang, Yilin, et al.
Publicado: (2012)

Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson’s Disease Mouse Model
por: Park, Jung-Eun, et al.
Publicado: (2023)

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway
por: Jing, Haoran, et al.
Publicado: (2017)

δ-opioid receptor activation protects against Parkinson’s disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy
por: Xu, Yuan, et al.
Publicado: (2020)

Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation
por: Li, Lin, et al.
Publicado: (2022)

NRF2, a Superstar of Ferroptosis
por: Yan, Ruihan, et al.
Publicado: (2023)

Activation of the δ-opioid receptor inhibits serum deprivation-induced apoptosis of human liver cells via the activation of PKC and the mitochondrial pathway
por: Tang, Bo, et al.
Publicado: (2023)

Structure of the δ-opioid receptor bound to naltrindole
por: Granier, Sébastien, et al.
Publicado: (2012)

Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD
por: Zhang, Zixiao, et al.
Publicado: (2021)

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
por: Claff, Tobias, et al.
Publicado: (2019)

A Critical Role of δ-Opioid Receptor in Anti-microglial Activation Under Stress
por: Xu, Yuan, et al.
Publicado: (2022)

Emodin attenuates diabetic kidney disease by inhibiting ferroptosis via upregulating Nrf2 expression
por: Ji, Jing, et al.
Publicado: (2023)

Restoration of intestinal function in an MPTP model of Parkinson’s Disease
por: Ellett, L. J., et al.
Publicado: (2016)

Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation
por: Song, Jiayu, et al.
Publicado: (2023)

Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons
por: Hong, J, et al.
Publicado: (2015)

Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation
por: Xu, Yang, et al.
Publicado: (2022)

Cytoprotection against Hypoxic and/or MPP(+) Injury: Effect of δ–Opioid Receptor Activation on Caspase 3
por: Xu, Yuan, et al.
Publicado: (2016)

Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors
por: Bao, Fenghua, et al.
Publicado: (2018)

Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity
por: Usenko, Tatiana, et al.
Publicado: (2023)

Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis
por: Huang, Yongzhou, et al.
Publicado: (2023)

Effects of adenosine receptor antagonists in MPTP mouse model of Parkinson’s disease: mitochondrial DNA integrity
por: Essawy, Soha S., et al.
Publicado: (2017)

The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
por: Zhang, Wenlong, et al.
Publicado: (2022)

Autotransphntation of the Cervical Sympathetic Ganglion into Monkeys With MPTP-Induced Parkinsonism
por: Itakura, Toru, et al.
Publicado: (1992)

Validity of the MPTP-Treated Mouse as a Model for Parkinson’s Disease
por: Klemann, Cornelius J. H. M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vr4v5p88mre5pbqk29lvk6s2cr