Inhibition of VDAC1 Rescues Aβ(1-42)-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β-Catenin Pathways

Beta-amyloid (Aβ) accumulation in the brains of Alzheimer's disease (AD) patients leads to mitochondrial dysfunction and ferroptosis in neurons. Voltage-dependent anion channel 1 (VDAC1) is a major protein in the mitochondrial outer membrane. It has been reported that VDAC1 associated with mito...

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Detalles Bibliográficos
Autores principales: Zhou, Xinpei, Tang, Ximin, Li, Tao, Li, Dandan, Gong, Zhiting, Zhang, Xiujun, Li, Yanjiao, Zhu, Jianhua, Wang, Yong, Zhang, Bensi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937775/
https://www.ncbi.nlm.nih.gov/pubmed/36816741
http://dx.doi.org/10.1155/2023/6739691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937775/
https://www.ncbi.nlm.nih.gov/pubmed/36816741
http://dx.doi.org/10.1155/2023/6739691

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