Epigenetic drug library screening reveals targeting DOT1L abrogates NAD(+) synthesis by reprogramming H3K79 methylation in uveal melanoma

Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis. However, a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains e...

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Detalles Bibliográficos
Autores principales: Gu, Xiang, Hua, Yu, Yu, Jie, Yang, Ludi, Ge, Shengfang, Jia, Renbing, Chai, Peiwei, Zhuang, Ai, Fan, Xianqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937798/
https://www.ncbi.nlm.nih.gov/pubmed/36820078
http://dx.doi.org/10.1016/j.jpha.2022.11.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937798/
https://www.ncbi.nlm.nih.gov/pubmed/36820078
http://dx.doi.org/10.1016/j.jpha.2022.11.008

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