The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway

Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in the Paris polyphylla. However, liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated. In this work, we found that PPI and PII exposure...

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Detalles Bibliográficos
Autores principales: Li, Zhiqi, Fan, Qiqi, Chen, Meilin, Dong, Ying, Li, Farong, Wang, Mingshuang, Gu, Yulin, Guo, Simin, Ye, Xianwen, Wu, Jiarui, Dai, Shengyun, Lin, Ruichao, Zhao, Chongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937801/
https://www.ncbi.nlm.nih.gov/pubmed/36820075
http://dx.doi.org/10.1016/j.jpha.2022.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937801/
https://www.ncbi.nlm.nih.gov/pubmed/36820075
http://dx.doi.org/10.1016/j.jpha.2022.11.005

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