Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells

Recombinant adeno-associated virus (rAAV) is a clinically proven viral vector for delivery of therapeutic genes to treat rare diseases. Improving rAAV manufacturing productivity and vector quality is necessary to meet clinical and commercial demand. These goals will require an improved understanding...

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Detalles Bibliográficos
Autores principales: Chung, Cheng-Han, Murphy, Christopher M., Wingate, Vincent P., Pavlicek, Jeffrey W., Nakashima, Reiko, Wei, Wei, McCarty, Douglas, Rabinowitz, Joseph, Barton, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937832/
https://www.ncbi.nlm.nih.gov/pubmed/36819978
http://dx.doi.org/10.1016/j.omtm.2023.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937832/
https://www.ncbi.nlm.nih.gov/pubmed/36819978
http://dx.doi.org/10.1016/j.omtm.2023.01.002

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