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Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells
Recombinant adeno-associated virus (rAAV) is a clinically proven viral vector for delivery of therapeutic genes to treat rare diseases. Improving rAAV manufacturing productivity and vector quality is necessary to meet clinical and commercial demand. These goals will require an improved understanding...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937832/ https://www.ncbi.nlm.nih.gov/pubmed/36819978 http://dx.doi.org/10.1016/j.omtm.2023.01.002 |