Cargando…

PCNA regulates primary metabolism by scaffolding metabolic enzymes

The essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA replication and repair are well established, while its cytosolic roles are less explored. Two metabolic enzymes, alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), both contain PCNA interacti...

Descripción completa

Detalles Bibliográficos
Autores principales: Røst, Lisa M., Ræder, Synnøve B., Olaisen, Camilla, Søgaard, Caroline K., Sharma, Animesh, Bruheim, Per, Otterlei, Marit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937922/
https://www.ncbi.nlm.nih.gov/pubmed/36564470
http://dx.doi.org/10.1038/s41388-022-02579-1