BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms

The tumour suppressor BRCA1-associated protein 1 (BAP1) is the most frequently mutated cancer gene in mesothelioma. Here we report novel functions for BAP1 in mitotic progression highlighting the relationship between BAP1 and control of genome stability in mesothelioma cells with therapeutic implica...

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Detalles Bibliográficos
Autores principales: Singh, Anita, Busacca, Sara, Gaba, Aarti, Sheaff, Michael, Poile, Charlotte, Nakas, Apostolos, Dzialo, Joanna, Bzura, Aleksandra, Dawson, Alan G., Fennell, Dean A., Fry, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937923/
https://www.ncbi.nlm.nih.gov/pubmed/36550359
http://dx.doi.org/10.1038/s41388-022-02577-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937923/
https://www.ncbi.nlm.nih.gov/pubmed/36550359
http://dx.doi.org/10.1038/s41388-022-02577-3

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