The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade

The incidence of colorectal cancer (CRC) is rising worldwide. Here, we identified SCNN1B as an outlier down-regulated in CRC and it functions as a tumor suppressor. SCNN1B mRNA and protein expression were down-regulated in primary CRC and CRC cells. In a tissue microarray cohort (N = 153), SCNN1B pr...

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Detalles Bibliográficos
Autores principales: Qian, Yun, Zhou, Lianxin, Luk, Simson Tsz Yat, Xu, Jiaying, Li, Weilin, Gou, Hongyan, Chen, Huarong, Kang, Wei, Yu, Jun, Wong, Chi Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937924/
https://www.ncbi.nlm.nih.gov/pubmed/36564468
http://dx.doi.org/10.1038/s41388-022-02576-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937924/
https://www.ncbi.nlm.nih.gov/pubmed/36564468
http://dx.doi.org/10.1038/s41388-022-02576-4

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