Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts

Systemic branched‐chain amino acid (BCAA) metabolism is dysregulated in cardiometabolic diseases. We previously demonstrated that upregulated AMP deaminase 3 (AMPD3) impairs cardiac energetics in a rat model of obese type 2 diabetes, Otsuka Long‐Evans‐Tokushima fatty (OLETF). Here, we hypothesized t...

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Detalles Bibliográficos
Autores principales: Ogawa, Toshifumi, Kouzu, Hidemichi, Osanami, Arata, Tatekoshi, Yuki, Sato, Tatsuya, Kuno, Atsushi, Fujita, Yugo, Ino, Shoya, Shimizu, Masaki, Toda, Yuki, Ohwada, Wataru, Yano, Toshiyuki, Tanno, Masaya, Miki, Takayuki, Miura, Tetsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938007/
https://www.ncbi.nlm.nih.gov/pubmed/36802195
http://dx.doi.org/10.14814/phy2.15608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938007/
https://www.ncbi.nlm.nih.gov/pubmed/36802195
http://dx.doi.org/10.14814/phy2.15608

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