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Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation

BACKGROUND: Body mass index (BMI) is known to influence the risk of various site-specific cancers, however, dissecting which subcomponents of this heterogenous risk factor are predominantly responsible for driving disease effects has proven difficult to establish. We have leveraged tissue-specific g...

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Detalles Bibliográficos
Autores principales: Leyden, Genevieve M., Greenwood, Michael P., Gaborieau, Valérie, Han, Younghun, Amos, Christopher I., Brennan, Paul, Murphy, David, Davey Smith, George, Richardson, Tom G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938133/
https://www.ncbi.nlm.nih.gov/pubmed/36434155
http://dx.doi.org/10.1038/s41416-022-02060-6