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Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Cellular cholesterol can be metabolized to its fatty acid esters, cholesteryl esters (CEs), to be stored in lipid droplets (LDs). With triacylglycerols (TGs), CEs represent the main neutral lipids in LDs. However, while TG melts at ~4 °C, CE melts at ~44 °C, raising the question of how CE-rich LDs f...

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Detalles Bibliográficos
Autores principales: Dumesnil, Calvin, Vanharanta, Lauri, Prasanna, Xavier, Omrane, Mohyeddine, Carpentier, Maxime, Bhapkar, Apoorva, Enkavi, Giray, Salo, Veijo T., Vattulainen, Ilpo, Ikonen, Elina, Thiam, Abdou Rachid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938224/
https://www.ncbi.nlm.nih.gov/pubmed/36807572
http://dx.doi.org/10.1038/s41467-023-36375-6