Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria

Thermorubin (THB) is a long-known broad-spectrum ribosome-targeting antibiotic, but the molecular mechanism of its action was unclear. Here, our precise fast-kinetics assays in a reconstituted Escherichia coli translation system and 1.96 Å resolution cryo-EM structure of THB-bound 70S ribosome with...

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Detalles Bibliográficos
Autores principales: Parajuli, Narayan Prasad, Emmerich, Andrew, Mandava, Chandra Sekhar, Pavlov, Michael Y., Sanyal, Suparna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938272/
https://www.ncbi.nlm.nih.gov/pubmed/36806263
http://dx.doi.org/10.1038/s41467-023-36528-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938272/
https://www.ncbi.nlm.nih.gov/pubmed/36806263
http://dx.doi.org/10.1038/s41467-023-36528-7

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