Cargando…

SIRT1/APE1 promotes the viability of gastric cancer cells by inhibiting p53 to suppress ferroptosis

Gastric cancer (GC) is a common cancer worldwide with high mortality. Sirtuin 1 (SIRT1) and apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) are abnormally expressed in GC cells and related to p53, which is involved in ferroptosis. Thus, we explore the mechanism via which SIRT1, APE1, and p53 im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Huijin, Ding, Yuanyi, Zhang, Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938643/ https://www.ncbi.nlm.nih.gov/pubmed/36820068 http://dx.doi.org/10.1515/med-2022-0620

Ejemplares similares

Resveratrol inhibits ferroptosis and decelerates heart failure progression via Sirt1/p53 pathway activation
por: Zhang, Wei, et al.
Publicado: (2023)

Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice
por: Cao, Yuanyuan, et al.
Publicado: (2023)

SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation
por: Su, Han, et al.
Publicado: (2023)

SIRT1 deacetylates APE1 and regulates cellular base excision repair
por: Yamamori, Tohru, et al.
Publicado: (2010)

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
por: Zhang, Qi, et al.
Publicado: (2012)

Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress
por: Jin, Ying, et al.
Publicado: (2020)

Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth
por: Zhang, Yizheng, et al.
Publicado: (2022)

SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
por: Antoniali, Giulia, et al.
Publicado: (2014)

Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy
por: Wang, Weichen, et al.
Publicado: (2021)

Sirt7 promotes adipogenesis by binding to and inhibiting Sirt1
por: Bober, Eva, et al.
Publicado: (2012)

SIRT2 promotes the viability, invasion and metastasis of osteosarcoma cells by inhibiting the degradation of Snail
por: Tian, Yonghao, et al.
Publicado: (2022)

Inhibition of Ape1 Redox Activity Promotes Odonto/osteogenic Differentiation of Dental Papilla Cells
por: Chen, Tian, et al.
Publicado: (2015)

Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression
por: Xue, Zhouyiyuan, et al.
Publicado: (2022)

ANXA1sp Protects against Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death via SIRT3-Mediated p53 Deacetylation
por: Qin, Song, et al.
Publicado: (2023)

Cytoglobin promotes sensitivity to ferroptosis by regulating p53‐YAP1 axis in colon cancer cells
por: Ye, Shazhou, et al.
Publicado: (2021)

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1–AMPK–ACC Pathway
por: Zhang, Mingjiong, et al.
Publicado: (2023)

GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail
por: Chen, Ling, et al.
Publicado: (2023)

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp
por: Hwang, Bor-Jang, et al.
Publicado: (2015)

ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation
por: Zhang, Xiuyuan, et al.
Publicado: (2022)

Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway
por: Busso, Carlos S., et al.
Publicado: (2009)

The APE1 Asp/Asp Genotype and the Combination of APE1 Asp/Asp and hOGG1-Cys Variants Are Associated With Increased p53 Mutation in Non–Small Cell Lung Cancer
por: Lin, Chun-Hsuan, et al.
Publicado: (2012)

Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathway
por: Liao, Yunfei, et al.
Publicado: (2023)

Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling
por: Zhang, Jiong, et al.
Publicado: (2020)

USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death
por: Ma, Shuxian, et al.
Publicado: (2020)

Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1
por: Kim, Sue Youn, et al.
Publicado: (2016)

Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
por: Zheng, Fang, et al.
Publicado: (2023)

Inhibition of Ape1 nuclease activity by lead, iron, and cadmium.
por: McNeill, Daniel R, et al.
Publicado: (2004)

Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation
por: Qu, Xingzhou, et al.
Publicado: (2021)

Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway
por: Ye, Guomei, et al.
Publicado: (2019)

Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs
por: Dell’Omo, Giulia, et al.
Publicado: (2019)

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage
por: Zaky, Amira, et al.
Publicado: (2008)

Prediction of Lymph Node Metastases in Gastric Cancer by Serum APE1 Expression
por: Wei, Xi, et al.
Publicado: (2017)

The p53-p21 pathway inhibits ferroptosis during metabolic stress
por: Tarangelo, Amy, et al.
Publicado: (2018)

Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT-1
por: Wang, Fei, et al.
Publicado: (2020)

Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT-1
por: Wang, Fei, et al.
Publicado: (2022)

Nicotinamide-mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis
por: WANG, TONG, et al.
Publicado: (2013)

PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis
por: Gnanapradeepan, Keerthana, et al.
Publicado: (2022)

PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1
por: Pinton, Giulia, et al.
Publicado: (2013)

From APE to APE-100: present and future of the APE project
por: Bacilieri, P, et al.
Publicado: (1988)

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer
por: Qing, Yi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kut7kkr67b0a3u156agann5lti