Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

The failure of metabolic tissues to appropriately respond to insulin (“insulin resistance”) is an early marker in the pathogenesis of type 2 diabetes. Protein phosphorylation is central to the adipocyte insulin response, but how adipocyte signaling networks are dysregulated upon insulin resistance i...

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Detalles Bibliográficos
Autores principales: Fazakerley, Daniel J., van Gerwen, Julian, Cooke, Kristen C., Duan, Xiaowen, Needham, Elise J., Díaz-Vegas, Alexis, Madsen, Søren, Norris, Dougall M., Shun-Shion, Amber S., Krycer, James R., Burchfield, James G., Yang, Pengyi, Wade, Mark R., Brozinick, Joseph T., James, David E., Humphrey, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938909/
https://www.ncbi.nlm.nih.gov/pubmed/36808134
http://dx.doi.org/10.1038/s41467-023-36549-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938909/
https://www.ncbi.nlm.nih.gov/pubmed/36808134
http://dx.doi.org/10.1038/s41467-023-36549-2

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