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TNF-α Regulates the Glucocorticoid Receptor Alpha Expression in Human Nasal Epithelial Cells Via p65-NF-κb and p38-MAPK Signaling Pathways

BACKGROUND: Tumor necrosis factor (TNF)-α induces changes in the glucocorticoid receptor (GR) isoforms’ expression in human nasal epithelial cells (HNECs) in chronic rhinosinusitis (CRS). OBJECTIVE: However, the underlying mechanism of TNF-α induced GR isoforms’ expression in HNECs remains unclear....

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Detalles Bibliográficos
Autores principales: Jiang, Yongquan, Liu, Bin, Bao, Ximing, Zhou, Pei, Li, Jiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Genetic Engineering and Biotechnology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938934/
https://www.ncbi.nlm.nih.gov/pubmed/36811108
http://dx.doi.org/10.30498/ijb.2022.298590.3117