Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies

Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells to refractory cancers but have shown limited efficacy in persistent, recurrent malignancies. Here, we introduce “CAR Pooling”, a multiplexed approach to rapidly identify CAR designs with clinical potential....

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Detalles Bibliográficos
Autores principales: Goodman, Daniel B., Azimi, Camillia S., Kearns, Kendall, Talbot, Alexis, Garakani, Kiavash, Garcia, Julie, Patel, Nisarg, Hwang, Byungjin, Lee, David, Park, Emily, Vykunta, Vivasvan S., Shy, Brian R., Ye, Chun Jimmie, Eyquem, Justin, Marson, Alexander, Bluestone, Jeffrey A., Roybal, Kole T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939256/
https://www.ncbi.nlm.nih.gov/pubmed/36350984
http://dx.doi.org/10.1126/scitranslmed.abm1463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939256/
https://www.ncbi.nlm.nih.gov/pubmed/36350984
http://dx.doi.org/10.1126/scitranslmed.abm1463

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