Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions

Neuronal hyperactivity induces memory deficits in Alzheimer’s disease. However, how hyperactivity disrupts memory is unclear. Using in vivo synaptic imaging in the mouse visual cortex, we show that structural excitatory-inhibitory synapse imbalance in the apical dendrites favors hyperactivity in ear...

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Detalles Bibliográficos
Autores principales: Niraula, Suraj, Doderer, Julia J., Indulkar, Shreya, Berry, Kalen P., Hauser, William L., L’Esperance, Oliver J., Deng, Jasmine Z., Keeter, Griffin, Rouse, Adam G., Subramanian, Jaichandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939293/
https://www.ncbi.nlm.nih.gov/pubmed/36640331
http://dx.doi.org/10.1016/j.celrep.2022.111946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939293/
https://www.ncbi.nlm.nih.gov/pubmed/36640331
http://dx.doi.org/10.1016/j.celrep.2022.111946

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