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Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions
Neuronal hyperactivity induces memory deficits in Alzheimer’s disease. However, how hyperactivity disrupts memory is unclear. Using in vivo synaptic imaging in the mouse visual cortex, we show that structural excitatory-inhibitory synapse imbalance in the apical dendrites favors hyperactivity in ear...
Autores principales: | Niraula, Suraj, Doderer, Julia J., Indulkar, Shreya, Berry, Kalen P., Hauser, William L., L’Esperance, Oliver J., Deng, Jasmine Z., Keeter, Griffin, Rouse, Adam G., Subramanian, Jaichandar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939293/ https://www.ncbi.nlm.nih.gov/pubmed/36640331 http://dx.doi.org/10.1016/j.celrep.2022.111946 |
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