Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) receptors. WLB-73502 is an antagonist at the S1R. It behaved as a partial MOR agonist at the G-protein...

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Detalles Bibliográficos
Autores principales: Vidal-Torres, Alba, Fernández-Pastor, Begoña, García, Mónica, Ayet, Eva, Cabot, Anna, Burgueño, Javier, Monroy, Xavier, Aubel, Bertrand, Codony, Xavier, Romero, Luz, Pascual, Rosalía, Serafini, Maria Teresa, Encina, Gregorio, Almansa, Carmen, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939367/
https://www.ncbi.nlm.nih.gov/pubmed/36815042
http://dx.doi.org/10.1016/j.apsb.2022.09.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939367/
https://www.ncbi.nlm.nih.gov/pubmed/36815042
http://dx.doi.org/10.1016/j.apsb.2022.09.018

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