Toward real-world automated antibody design with combinatorial Bayesian optimization

Antibodies are multimeric proteins capable of highly specific molecular recognition. The complementarity determining region 3 of the antibody variable heavy chain (CDRH3) often dominates antigen-binding specificity. Hence, it is a priority to design optimal antigen-specific CDRH3 to develop therapeu...

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Detalles Bibliográficos
Autores principales: Khan, Asif, Cowen-Rivers, Alexander I., Grosnit, Antoine, Deik, Derrick-Goh-Xin, Robert, Philippe A., Greiff, Victor, Smorodina, Eva, Rawat, Puneet, Akbar, Rahmad, Dreczkowski, Kamil, Tutunov, Rasul, Bou-Ammar, Dany, Wang, Jun, Storkey, Amos, Bou-Ammar, Haitham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939385/
https://www.ncbi.nlm.nih.gov/pubmed/36814835
http://dx.doi.org/10.1016/j.crmeth.2022.100374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939385/
https://www.ncbi.nlm.nih.gov/pubmed/36814835
http://dx.doi.org/10.1016/j.crmeth.2022.100374

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