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Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose
Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model. However, it is still less clear if GO-Y022 affects tumor-induced immune suppression. In this study, we found that GO-Y022 inhibited Treg generation in the presence of transforming growth factor beta 1 (TGF-β...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939626/ https://www.ncbi.nlm.nih.gov/pubmed/36814928 http://dx.doi.org/10.3389/fimmu.2023.1049713 |
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author | MaruYama, Takashi Miyazaki, Hirofumi Lim, Yun-Ji Gu, Jian Ishikawa, Masaki Yoshida, Taichi Chen, WanJun Owada, Yuji Shibata, Hiroyuki |
author_facet | MaruYama, Takashi Miyazaki, Hirofumi Lim, Yun-Ji Gu, Jian Ishikawa, Masaki Yoshida, Taichi Chen, WanJun Owada, Yuji Shibata, Hiroyuki |
author_sort | MaruYama, Takashi |
collection | PubMed |
description | Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model. However, it is still less clear if GO-Y022 affects tumor-induced immune suppression. In this study, we found that GO-Y022 inhibited Treg generation in the presence of transforming growth factor beta 1 (TGF-β). However, GO-Y022 showed less impact on Foxp3(+) Tregs in the gastric tumor microenvironment. Gastric tumor cells produce a large amount of L-lactate in the presence of GO-Y022 and diminish the inhibitory role of GO-Y022 against Treg generation in response to TGF-β. Therefore, naïve CD4(+) T cells co-cultured with GO-Y022 treated gastric tumor cells increased Treg generation. GO-Y022-induced tumor cell death was further enhanced by 2-deoxy-d-glucose (2DG), a glycolysis inhibitor. Combination treatment of GO-Y022 and 2DG results in reduced L-lactate production and Treg generation in gastric tumor cells. Overall, GO-Y022-treatment with restricted glucose metabolism inhibits gastric tumor cell survival and promotes anti-tumor immunity. |
format | Online Article Text |
id | pubmed-9939626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99396262023-02-21 Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose MaruYama, Takashi Miyazaki, Hirofumi Lim, Yun-Ji Gu, Jian Ishikawa, Masaki Yoshida, Taichi Chen, WanJun Owada, Yuji Shibata, Hiroyuki Front Immunol Immunology Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model. However, it is still less clear if GO-Y022 affects tumor-induced immune suppression. In this study, we found that GO-Y022 inhibited Treg generation in the presence of transforming growth factor beta 1 (TGF-β). However, GO-Y022 showed less impact on Foxp3(+) Tregs in the gastric tumor microenvironment. Gastric tumor cells produce a large amount of L-lactate in the presence of GO-Y022 and diminish the inhibitory role of GO-Y022 against Treg generation in response to TGF-β. Therefore, naïve CD4(+) T cells co-cultured with GO-Y022 treated gastric tumor cells increased Treg generation. GO-Y022-induced tumor cell death was further enhanced by 2-deoxy-d-glucose (2DG), a glycolysis inhibitor. Combination treatment of GO-Y022 and 2DG results in reduced L-lactate production and Treg generation in gastric tumor cells. Overall, GO-Y022-treatment with restricted glucose metabolism inhibits gastric tumor cell survival and promotes anti-tumor immunity. Frontiers Media S.A. 2023-02-06 /pmc/articles/PMC9939626/ /pubmed/36814928 http://dx.doi.org/10.3389/fimmu.2023.1049713 Text en Copyright © 2023 MaruYama, Miyazaki, Lim, Gu, Ishikawa, Yoshida, Chen, Owada and Shibata https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology MaruYama, Takashi Miyazaki, Hirofumi Lim, Yun-Ji Gu, Jian Ishikawa, Masaki Yoshida, Taichi Chen, WanJun Owada, Yuji Shibata, Hiroyuki Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose |
title | Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose |
title_full | Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose |
title_fullStr | Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose |
title_full_unstemmed | Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose |
title_short | Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose |
title_sort | pyrolyzed deketene curcumin controls regulatory t cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939626/ https://www.ncbi.nlm.nih.gov/pubmed/36814928 http://dx.doi.org/10.3389/fimmu.2023.1049713 |
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