Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway

Cutaneous pigmentation was recently shown to be an event regulated by clock proteins. Cryptochrome (CRY) is a key protein composing the feedback loop of circadian clock, however, the function of CRY in melanocytes remains unclear. Here, we found that KL001, a synthetic small molecule modulator of CR...

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Detalles Bibliográficos
Autores principales: Gao, Rongyin, Zhang, Ximei, Zou, Kun, Meng, Duo, Lv, Jinpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939694/
https://www.ncbi.nlm.nih.gov/pubmed/36814484
http://dx.doi.org/10.3389/fphar.2023.1081030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939694/
https://www.ncbi.nlm.nih.gov/pubmed/36814484
http://dx.doi.org/10.3389/fphar.2023.1081030

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