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Sodium/(calcium + potassium) exchanger NCKX4 optimizes KLK4 activity in the enamel matrix microenvironment to regulate ECM modeling
Enamel development is a process in which extracellular matrix models from a soft proteinaceous matrix to the most mineralized tissue in vertebrates. Patients with mutant NCKX4, a gene encoding a K(+)-dependent Na(+)/Ca(2+)—exchanger, develop a hypomineralized and hypomature enamel. How NCKX4 regulat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939835/ https://www.ncbi.nlm.nih.gov/pubmed/36814474 http://dx.doi.org/10.3389/fphys.2023.1116091 |