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Sodium/(calcium + potassium) exchanger NCKX4 optimizes KLK4 activity in the enamel matrix microenvironment to regulate ECM modeling

Enamel development is a process in which extracellular matrix models from a soft proteinaceous matrix to the most mineralized tissue in vertebrates. Patients with mutant NCKX4, a gene encoding a K(+)-dependent Na(+)/Ca(2+)—exchanger, develop a hypomineralized and hypomature enamel. How NCKX4 regulat...

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Detalles Bibliográficos
Autores principales:	Chan, Barry, Cheng, Ieong Cheng, Rozita, Jalali, Gorshteyn, Ida, Huang, Yulei, Shaffer, Ida, Chang, Chih, Li, Wu, Lytton, Jonathan, Den Besten, Pamela, Zhang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939835/ https://www.ncbi.nlm.nih.gov/pubmed/36814474 http://dx.doi.org/10.3389/fphys.2023.1116091

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