From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination

Commercially available iron salts FeX(2) are remarkably active catalysts for pyrrolidine formation from organic azides via direct C–H bond amination. With FeI(2), amination is fast and selective, (<30 min for 80% yield at 2 mol% loading), TONs up to 370 are reached with just 0.1 mol% catalyst, di...

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Detalles Bibliográficos
Autores principales: Stroek, Wowa, Hoareau, Lilian, Albrecht, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939938/
https://www.ncbi.nlm.nih.gov/pubmed/36825222
http://dx.doi.org/10.1039/d2cy02065c
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author Stroek, Wowa
Hoareau, Lilian
Albrecht, Martin
author_facet Stroek, Wowa
Hoareau, Lilian
Albrecht, Martin
author_sort Stroek, Wowa
collection PubMed
description Commercially available iron salts FeX(2) are remarkably active catalysts for pyrrolidine formation from organic azides via direct C–H bond amination. With FeI(2), amination is fast and selective, (<30 min for 80% yield at 2 mol% loading), TONs up to 370 are reached with just 0.1 mol% catalyst, different functional groups are tolerated, and a variety of C–H bonds were activated.
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spelling pubmed-99399382023-02-21 From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination Stroek, Wowa Hoareau, Lilian Albrecht, Martin Catal Sci Technol Chemistry Commercially available iron salts FeX(2) are remarkably active catalysts for pyrrolidine formation from organic azides via direct C–H bond amination. With FeI(2), amination is fast and selective, (<30 min for 80% yield at 2 mol% loading), TONs up to 370 are reached with just 0.1 mol% catalyst, different functional groups are tolerated, and a variety of C–H bonds were activated. The Royal Society of Chemistry 2023-01-25 /pmc/articles/PMC9939938/ /pubmed/36825222 http://dx.doi.org/10.1039/d2cy02065c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Stroek, Wowa
Hoareau, Lilian
Albrecht, Martin
From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination
title From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination
title_full From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination
title_fullStr From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination
title_full_unstemmed From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination
title_short From the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic C–H bond amination
title_sort from the bottle: simple iron salts for the efficient synthesis of pyrrolidines via catalytic c–h bond amination
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939938/
https://www.ncbi.nlm.nih.gov/pubmed/36825222
http://dx.doi.org/10.1039/d2cy02065c
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