Genomic and biological aspects of resistance to selective poly(ADP‐ribose) glycohydrolase inhibitor PDD00017273 in human colorectal cancer cells

BACKGROUND: Poly(ADP‐ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP‐ribose) (PAR) metabolism and a potential anticancer target. Many drug candidates have been developed to inhibit its enzymatic activity. Additionally, PDD00017273 is an effective and selective inhibitor of PARG at the firs...

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Detalles Bibliográficos
Autores principales: Tsuda, Kaede, Kurasaka, Chinatsu, Ogino, Yoko, Sato, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939995/
https://www.ncbi.nlm.nih.gov/pubmed/36053937
http://dx.doi.org/10.1002/cnr2.1709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9939995/
https://www.ncbi.nlm.nih.gov/pubmed/36053937
http://dx.doi.org/10.1002/cnr2.1709

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