Cooperative induction of receptor tyrosine kinases contributes to adaptive MAPK drug resistance in melanoma through the PI3K pathway

Vemurafenib‐induced drug resistance in melanoma has been linked to receptor tyrosine kinase (RTK) upregulation. The MITF and SOX10 genes play roles as master regulators of melanocyte and melanoma development. Here, we aimed to explore the complex mechanisms behind the MITF/SOX10‐controlled RTK‐induc...

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Detalles Bibliográficos
Autores principales: Alver, Tine Norman, Heintz, Karen‐Marie, Hovig, Eivind, Bøe, Sigurd L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940011/
https://www.ncbi.nlm.nih.gov/pubmed/36251678
http://dx.doi.org/10.1002/cnr2.1736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940011/
https://www.ncbi.nlm.nih.gov/pubmed/36251678
http://dx.doi.org/10.1002/cnr2.1736

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