Familial Alzheimer’s Disease-Related Mutations Differentially Alter Stability of Amyloid-Beta Aggregates

[Image: see text] Amyloid-beta (Aβ) deposition as senile plaques is a pathological hallmark of Alzheimer’s disease (AD). AD is characterized by a large level of heterogeneity in amyloid pathology, whose molecular origin is poorly understood. Here, we employ NMR spectroscopy and MD simulation at ambi...

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Detalles Bibliográficos
Autores principales: Rezaei-Ghaleh, Nasrollah, Amininasab, Mehriar, Giller, Karin, Becker, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940190/
https://www.ncbi.nlm.nih.gov/pubmed/36734539
http://dx.doi.org/10.1021/acs.jpclett.2c03729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940190/
https://www.ncbi.nlm.nih.gov/pubmed/36734539
http://dx.doi.org/10.1021/acs.jpclett.2c03729

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