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Familial Alzheimer’s Disease-Related Mutations Differentially Alter Stability of Amyloid-Beta Aggregates

[Image: see text] Amyloid-beta (Aβ) deposition as senile plaques is a pathological hallmark of Alzheimer’s disease (AD). AD is characterized by a large level of heterogeneity in amyloid pathology, whose molecular origin is poorly understood. Here, we employ NMR spectroscopy and MD simulation at ambi...

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Detalles Bibliográficos
Autores principales:	Rezaei-Ghaleh, Nasrollah, Amininasab, Mehriar, Giller, Karin, Becker, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940190/ https://www.ncbi.nlm.nih.gov/pubmed/36734539 http://dx.doi.org/10.1021/acs.jpclett.2c03729

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